breath analysis in asbestos-related disorders: a review of the literature and potential future applications
電子鼻技術(shù)用于石棉引發(fā)呼吸疾病診斷應(yīng)用研究
eleanor a chapman1, paul s thomas1 and deborah h yates2,3
abstract
asbestos usage was very common worldwide in the last century and continues in several countries today. several diseases occur due to asbestos exposure, including malignant tumours such as malignant mesothelioma of the pleura and lung cancer, which have a very poor prognosis. asbestos inhalation may also result in more benign conditions such as asbestosis (or pulmonary fibrosis due to asbestos), pleural plaques and pleural thickening. it is predicted that asbestos-associated mortality and morbidity will continue to increase, but methods for diagnosing asbestos-related disease are currently invasive and unsuitable for an increasingly elderly population. new non-invasive methods such as analysis of exhaled breath biomarkers e.g. exhaled nitric oxide (f(e)no), exhaled breath condensate or of exhaled volatile organic compounds could potentially be extremely useful in these conditions. this article reviews the current literature on this topic and suggests areas for their application in the future.
石棉的使用在上個(gè)世紀(jì)在世界范圍內(nèi)非常普遍，今天仍在幾個(gè)國家繼續(xù)使用。石棉暴露可導(dǎo)致多種疾病，包括惡性腫瘤，如胸膜惡性間皮瘤和肺癌，預(yù)后極差。吸入石棉也可能導(dǎo)致良性疾病，如石棉肺(或石棉引起的肺纖維化)、胸膜斑塊和胸膜增厚。據(jù)預(yù)測，石棉相關(guān)的死亡率和發(fā)病率將繼續(xù)增加，但目前診斷石棉相關(guān)疾病的方法是侵入性的，不適合日益老齡化的人群。新的非侵入性方法，如分析呼出的呼吸生物標(biāo)志物，如呼出的一氧化氮(f(e)no)、呼出的呼吸冷凝液或呼出的揮發(fā)性有機(jī)化合物，在這些情況下可能非常有用。本文回顧了有關(guān)這一主題的現(xiàn)有文獻(xiàn)，并提出了今后的應(yīng)用領(lǐng)域。
electronic noses (cyranose 320)have been successfully used to distinguish breath samples from patients with lung cancer from control subjects, with high accuracy, specificity and sensitivity. lung cancer secondary to asbestos exposure is clinically indistinguishable from lung cancer due to other causes, so it would be expected that results in this group would be similar. however, the profile could be altered by the presence of other asbestos-related disorders such as pleural plaques or
asbestosis, and thus studies are currently evaluating the voc profile of subjects with asbestos-related disorders. however, no information is yet available in this area. the literature onlung cancer is summarized below .
電子鼻(cyranose320)已成功地用于區(qū)分肺癌患者和對(duì)照組的呼吸樣本，具有較高的準(zhǔn)確性、特異性和敏感性。由于石棉暴露引起的肺癌在臨床上與其他原因引起的肺癌是不可區(qū)分的，因此這一組的結(jié)果應(yīng)該是相似的。然而，其他石棉相關(guān)疾病如胸膜斑塊或石棉中毒，因此研究目前正在評(píng)估與石棉相關(guān)疾病的受試者的voc特征。然而，目前還沒有這方面的信息。關(guān)于癌癥的文獻(xiàn)總結(jié)如下。