5-氮雜-2′-脫氧胞苷
5-氮雜-2′-脫氧胞苷
性質(zhì)
related categories an-az,approved therapeutics/drug candidates,bioactive small molecule alphabetical index,eisai,fluorination ready pharma-developed compounds,
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inchi key xaudjqyhkzqpeu-kvqbguixsa-n
assay ≥97%
solubility acetic acid: water (1:1): 50mg/ml
originator eisai
產(chǎn)品描述
包裝
5, 10 mg in glass bottle
50 mg in glass insert
application
5-aza-2′-deoxycytidine has been used as a demethylating agent in breast cancer cell line, chromatin, dna and promoter region of p16 gene.[3][4][5][6]
biochem/physiol actions
5′-脫氧雜氮胞苷可引起dna去甲基化或半去甲基化。dna去甲基化可通過(guò)隨著提高的核酸酶活性而“打開(kāi)”染色質(zhì)的結(jié)構(gòu)來(lái)調(diào)控基因的表達(dá)。這種染色質(zhì)結(jié)構(gòu)的重塑可實(shí)現(xiàn)轉(zhuǎn)錄因子與啟動(dòng)子區(qū)域的結(jié)合、轉(zhuǎn)錄復(fù)合物的組裝及基因表達(dá)。
features and benefits
該化合物是基因調(diào)控研究的特色產(chǎn)品。點(diǎn)擊此處以了解更多的基因調(diào)控特色產(chǎn)品。
該化合物由eisai開(kāi)發(fā)。
5-aza-2′-deoxycytidine is a dna-hypomethylating agent, which stimulates differentiation and apoptosis of leukemic cells.[1]it is a 2′-deoxycytidine analogue.[2]5-aza-2′-deoxycytidine is used to treat chronic myelomonocytic leukemia, refractory anemia, myelodysplastic syndrome and acute myeloid leukemia.